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[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Samms RJ, Coghlan MP, Sloop KW

Extra fat cells act like mini chemical factories, releasing hormones and inflammatory messengers called cytokines, such as interleukin-6 (IL-6), Tumor necrosis factor alpha (TNF-alpha), interleukin-17 (IL-17), and others

Pharmacodynamics Tirzepatide is a GIP/GLP-1 chimeric peptide with a peptide chain length of 39 amino acids

Caveats and Clinical Context While the oral Wegovy pill is a major advancement, several important factors remain: Side Effects: Like all GLP-1s, the pill carries gastrointestinal side effects (nausea, diarrhea), which can impact adherence