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Ultimately, the decision to pursue weight management in older adults should be individualised, taking into account the patient's goals, quality of life, functional status, and life expectancy

in the 2021 survey from GI Society, 91% of respondents reported comorbidities such as arthritis (51%), hypertension (33%), sleep apnea (30%), gastroesophageal reflux disease (29%), irritable bowel syndrome (29%), high cholesterol (25%), and diabetes (24%)

cAMP directly activates protein kinase A (PKA) and cAMP-regulated guanine nucleotide exchange factor 2 (Epac2), that act synergistically to generate downstream signals resulting in increased insulin secretion (8)

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