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Both medications also cause your rate of digestion to slow, allowing you to feel fuller for longer as food makes its way through your system.1 But in addition to being a GLP-1 receptor agonist, tirzepatide has a second, more pronounced mechanism of action regarding glucose-dependent insulinotropic polypeptide (GIP).4 Well get into the weeds on how each peptide is responsible for the drugs weight loss and antidiabetic effects a little later on, but a simple, convincing bit of comparison comes from a pair of studies conducted in the past few years

Additionally, Shah and collaborators showed that the DPP4-inhibitor linagliptin protects isolated human islets from gluco-, lipo-, and cytokine-toxicity (132)

Studies have reported that consuming 1.2 1.6 grams per kilogram of body weight can be more beneficial in the context of conditions such as type 2 diabetes or metabolic syndrome

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