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Recently, a randomized, double-blind, placebo-controlled trial in 295 patients with Alzheimers disease found that DHA supplementation (2 grams/day) for 18 months was not effective in slowing cognitive decline (129)

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This, in turn, triggers the HIF1A (hypoxia inducible factor 1 subunit alpha)-dependent Warburg effect and AIM2 (absent in melanoma 2)-dependent inflammasome activation, contributing to Kras G12D -induced pancreatic tumorigenesis [212]