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In animal models, this alcohol-induced reward is characterized by activation of the mesolimbic dopamine system, and it can be studied in preclinical models that involve hyperlocomotion, dopamine release in the NAc, and reward in the conditioned place preference (CPP) paradigm (Sanchis-Segura and Spanagel, 2006)

10.3389/fendo.2021.770986 [DOI] [PMC free article] [PubMed] [Google Scholar] Khalifa O., Ouararhni K., Errafii K., Alajez N

doi: 10.1007/s12012-021-09656-z 34 BorgesNAStenvinkelPBergmanPQureshiARLindholmBMoraesCet al

Interestingly, changes in calcium homeostasis in the brain may contribute to the cognitive decline associated with normal aging and possibly to the development of neurodegenerative disorders (61, 62)