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A deeper understanding of these interconnected metabolic networks clarifies the critical role of ferroptosis in OA progression and lays a robust foundation for integrated therapeutic strategies targeting both metabolic reprogramming and ferroptosis

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This precise enzymatic action releases the fully intact, active, reduced glutathione directly into the cytoplasm, exactly where the mitochondria and cellular machinery need it to neutralize oxidative stress

Then, NIH ImageJ (National Institutes of Health (NIH), MD, United States) software was used to quantify the band intensities