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Pyo and colleagues showed that GHK-Cu at concentrations as low as 1 M promoted dermal papilla cell proliferation and beta-catenin signaling in mouse models

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(More information) Some evidence from small randomized controlled studies suggests that high-dose lipoic acid may improve measures of glucose utilization in subjects with metabolic disorders

Evidence Tier Framework Tier 1 FDA-approved therapy large randomized trials Tier 2 human trials demonstrating biological effect Tier 3 small human studies or limited clinical data Tier 4 animal models or anecdotal reports Stacking should generally involve: at least one Tier 1 therapy no more than one Tier 3 compound Stacks composed entirely of Tier 34 compounds should not be considered clinical protocols