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We observed that sUA also activates the NLRP3 inflammasome through ion flux, specifically via potassium efflux, since the inhibition of cellular K + removal in WT macrophages also inhibited IL-1 production (Sup

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The emerging role of macrophages in chronic obstructive pulmonary disease: the potential impact of oxidative stress and extracellular vesicle on macrophage polarization and function