Bitter orange : Chest pain, anxiety, headache, musculoskeletal complaints, high blood pressure, increased heart rate Capsaicin : Gastrointestinal distress, increased insulin levels, decreased high-density lipoprotein (HDL) levels Conjugated linoleic acid (CLA) : Abdominal discomfort and pain, constipation, diarrhea, loose stools, dyspepsia Garcinia cambogia (hydroxycitric acid) : Headache, nausea, upper respiratory tract symptoms, gastrointestinal symptoms, mania, liver damage Green coffee bean extract : Headache, urinary tract infections Green tea extract : Constipation, abdominal discomfort, nausea, increased blood pressure, liver damage Yohimbe : Headache, anxiety, agitation, hypertension, tachycardia, myocardial infarction, cardiac failure Its important to use supplements containing these ingredients responsibly, as these side effects may occur when taken in excess or with certain medical conditions

Recently, it has been suggested that this harmful active microglia of the acute stage may have beneficial effects when it appears in delayed stages (100)
The Cochrane Database of Systematic Reviews (3) CD004326
Author contributions SHN: Conceptualization, Data curation, Formal Analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writingoriginal draft