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They remain licensed only for type 2 diabetes and obesity, and any use for alcohol problems would be off-label

14,15 Potential Direct Effects on the Heart Although the systemic indirect effects of GLP-1RAs are well established as the primary drivers of their clinical benefit in HF, emerging preclinical and mechanistic evidence suggests GLP-1RAs may also exert some direct cardioprotective effects, as discussed below

The two of them first met by chance at a meeting organised by the Medical Research Society when Samols was hunting for someone to help with his venture

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