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Chronic constipation patients have reduced EC cell density, decreased 5-HT synthesis, and significantly lowered colonic tissue 5-HT concentrations ( 3.2.2 Neuroendocrine alterations Neuroendocrine system dysregulation represents an important pathophysiological mechanism in chronic constipation and depression comorbidity, involving abnormalities in the HPA axis, hypothalamic-pituitary-thyroid (HPT) axis, and various gastrointestinal hormones (Konturek et al., 2011)
Special Considerations For Vegetarians and Vegans Protein sources : Tofu, tempeh, seitan, legumes, plant protein powders Challenge : Getting 1.2-1.6g/kg without animal protein requires planning Supplement consideration : B12, iron, and zinc are worth monitoring For People with Diabetes Monitor blood sugar closely, especially in the first weeks Work with your doctor to adjust diabetes medications as needed The combination of GLP-1 + very low carb diet can cause hypoglycemia if youre on insulin or sulfonylureas The Bottom Line The GLP-1 diet isnt a fad its a strategic approach to eating that complements the medications effects while protecting your health
