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Cardiovascular data on endpoints like MACE-3 or MACE-4 are presently not available yet, but an early meta-analysis demonstrated at least cardiovascular safety in patients with T2D treated with tirzepatide (78, 79)
Compound movements targeting major muscle groups produce the strongest systemic response
The most common were nausea, vomiting and constipation, which aligned with what clinical trials found, according to Sehgal
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