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All statistical analyses were performed using SAS Enterprise Guide version 7.15 (2017, SAS Institute Inc., Cary, NC, USA), R version 4.0.3 (R Core Team, 2020, and additional R packages (MatchIt, meta)

There was a weak correlation between weight loss and SBP in the pooled analyses across SURPASS trials which further raises curiosity to explore potential weight-loss independent mechanisms that could be driving the reduction in SBP

(Riederer 2022) Oxcarbazine metabolite (MHD) levels : Not routinely required for most patients