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Epithalon and the Telomere Connection Among the most studied longevity peptides in preclinical literature is Epithalon, a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from epithalamin, a natural extract of the pineal gland

Community sources consistently describe improved energy levels and sleep quality as the first noticeable effects, particularly with IV and injectable routes

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While these receptors are present at the synapse between inner hair cells and spiral ganglion neurons, their activation in the mature cochlea is often linked to excitotoxicity, with ototoxic drugs like aspirin enabling their response (Wang et al., 2021)