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Aging of the immune system causes reductions in muscle stem cell populations, promotes their shift to a fibrogenic phenotype, and modulates sarcopenia

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This is attributed to Lewy body pathology in cortical regions, cholinergic depletion, and altered frontostriatal connectivity

(2016) The proteasome inhibitor lactacystin enhances GSH synthesis capacity by increased expression of antioxidant components in an Nrf2-independent, but p38 MAPK-dependent manner in rat colorectal carcinoma cells, Free Radic