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The researchers found that the mechanism by which metformin stimulates GLP-1 release involves two G-protein-coupled receptors, the M3 cholinergic receptor and the GRP receptor (Mulherin et al., 2011)

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Research in rodent models has characterized MC4R-mediated effects on food intake suppression, energy expenditure, and autonomic outflow, establishing MT-2 as a widely used pharmacological tool for probing central melanocortin circuitry (Huszar et al., Cell, 1997