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Importantly, these methods have fewer neurotoxic effects than traditional whole-brain radiation therapy (WBRT), therefore leading to less cognitive deterioration [5, 6]

Cognitive engagement is about keeping mentally active through new and challenging activities (e.g., taking classes, learning new skills or a new language, reading difficult material or learning to play a challenging strategy game)

GST protects cells against foreign compounds such as carcinogens and drugs by catalyzing the attachment of glutathione to the compounds electrophilic and/or hydrophobic sites.BioAssay Systems Glutathione S-transferase assay kit is based on the GST enzyme reaction between GSH and the GST substrate, CDNB (1-chloro-2,4-dinitrobenzene)

in addition, some questions remain about the long-term safety of bisphosphonate use (Suresh 2014)