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From dramatic weight loss journeys to improved health markers and enhanced self-esteem, the testimonials presented a compelling picture of the potential benefits of GLP-1 receptor agonists

GIP receptors may enhance insulin response and further reduce hunger signals

There are no "off days" where the medication effect diminishes

Still, to pave the way for more widespread clinical applications of gut-based interventions, future research will need to shift emphasis on more reward phases and clinical populations, ideally using larger samples with publication of the associations regardless of their threshold as full maps and regardless of a potential confirmation or rejection of the hypothesized action on reward responses