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Symptoms Polycystic ovary syndrome usually does not cause symptoms before mid-puberty, when the ovaries begin to produce hormones in significant amounts

therefore, becoming an important target to regulate glucose levels via the administration of HDAC inhibitors like metformin (a first-line antihyperglycemic drug for T2DM treatment) (82, 83)

doi: 10.3389/fddsv.2026.1792418 Received 20 January 2026 Revised 11 March 2026 Accepted 16 March 2026 Published 10 April 2026 Volume 6 - 2026 Edited by Liang Xu, University of Kansas, United States Reviewed by Christel Menet, Confo Therapeutics, Belgium Anukriti Saran, Banasthali University, India Updates Copyright 2026 Niazi

Compounders can still make alternative versions of the drugs if they modify doses, add other ingredients, or change the route of administration in compliance with FDA rules