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Metabolic stress, calcium dysregulation and neuroinflammation mediated by glial cells like astrocytes and microglia further exacerbates RGC loss ( In many eye diseases, oxidative stress and mitochondrial dysfunction are key contributors to RGC degeneration

In some embodiments, the otic formulation or composition comprises about 8% by weight of the poloxamer

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However, this characterisation requires careful scrutiny