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[4] Systemic estradiol therapy is contraindicated in patients with unexplained vaginal bleeding, active or history of estrogen-dependent malignancies such as breast carcinoma, active deep-vein thrombosis or pulmonary embolism, and in those with known hereditary or acquired thrombophilias because of the heightened pro-coagulant milieu engendered by estrogen exposure

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2013 May 31 ;14(6):11742-66

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This rise in deaths due to overdose was driven by increased lethal overdose of nearly all drug classes studied (including opioids, benzodiazepines, and stimulants)

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NOW Foods was founded in 1968 to promote healthy living

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