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Common side effects include nausea, diarrhea, and mild gastrointestinal discomfort, usually dose-dependent

Most participants experienced noticeable appetite reduction within the first 3 to 4 weeks, with visible weight changes becoming apparent by week 8

Exendin-4 increases intracellular cAMP levels in colon cancer CT26 cells, activates the PKA pathway, and inhibits the activity of signaling kinases GSK3 and ERK1/2, consequently suppressing CT26 cell proliferation (152)