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Nonetheless, whether the specific mechanism of this is related to the transdifferentiation of VSMCs to a bone-like phenotype, loss in SMC lineage markers, enhanced pro-calcific microRNAs, increased intracellular calcium level, apoptosis, or aberrant DNA damage response (DDR) requires further investigation

First isolated and characterized by Sikiric et al

Restoring active glutathione (GSH) levels and the ratio of active reduce to inactive oxidized GSH/GSSG can correct some, if not all, of the energy depletion

Immunohistochemistry Immunohistochemistry (IHC), utilizing fluorescent or chromogen tagged antibodies, is a useful adjunct for identification of different cell types in the liver