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34 In human research, administration of prebiotic fiber has been associated with a significant decrease in hunger, significantly greater satiation after meals and increased plasma GLP-1 levels

By month seven, most participants reported essentially zero side effects apart from the appetite suppression that the medication is designed to produce

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Recently, a phase II multicentre, double-blind, randomized controlled trial including 338 adults with obesity were administered retatrutide (1, 2 mg starting dose increased to 4, 2 mg starting dose increased to 8, 2 mg starting dose increased to 12 mg) compared to placebo over 48 weeks [64]