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Techniques like photodamage can rapidly induce retinal deterioration within a matter of hours or days, but they do not adequately replicate the prolonged, recurring mild oxidative stress and the complex interplay of metabolic, inflammatory, and genetic factors found in human AMD/DR

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The copper ion is what gives the peptide its biological activity: it binds to TGF-beta receptors on fibroblasts, upregulates metalloproteinase inhibitors (TIMPs), and directly stimulates collagen gene expression

2018 Jan;175:23-28