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In a mouse model of pressure-overload heart failure, the inhibitor significantly alleviated myocardial remodeling and dysfunction by inhibiting H 2 S degradation, demonstrating the feasibility of targeting the H 2 S metabolic pathway for treating heart failure

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Several resting-state fMRI studies have reported altered functional connectivity in brain regions involved in cognitive control and emotional processing, including the prefrontal cortex, hippocampal and parahippocampal regions, and the cingulate cortex, in patients with ME/CFS