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Contact your GP if you experience any of the following: Unexplained weight gain of more than 23 kg within approximately one week, which may indicate fluid retention or another underlying condition New or worsening ankle or leg swelling, particularly if accompanied by breathlessness seek same-day advice in this case Symptoms of hypotension (dizziness, fainting, or persistent fatigue), particularly after starting a weight loss programme

20 patients aged 50 to 75, all with obesity and knee osteoarthritis

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