Int J Mol Sci 23(1):471 Niu Y, Wang L, Chen Y, Zhou J, Sun W (2025) Analysis of melatonin simulated metabolism based on electrochemistry coupled online with high performance liquid chromatographymass spectrometry
Statistical analyses Pharmacokinetic and statistical analyses were performed using GraphPad Prism Version 9
This was confirmed by clonogenic assays that showed that cells treated with MT displayed significantly decreased surviving fraction (Fig
Prebiotic and probiotic use may help reduce TMAO production: Administration of probiotic Lacticaseibacillus paracasei , but not Lacticaseibacillus casei, or Lactiplantibacillus plantarum , may reduce circulating TMA and TMAO levels Enterobacter aerogenes ZDY01 increased Bacteroidales ( Bacterodetes phylum) and decreased Prevotellaceae and Helicobacteraceae families Supplementing with Archeobacteria phylum, may reduce TMA and TMAO The prebiotic Arabinoxylan oligosaccharide plus vitamins B and D showed a small reduction in serum TMAO Prebiotics such as resveratrol increased the Bacterodetes phylum, while Firmicutes , aside from Lactobacillus and Bifidobacterium genus, decreased along with TMAO plasma levels Physical activity has a favorable effect on gut microbiota composition Some natural products, including 3,3-dimethyldimetyl-1-butanol (DMB) from vinegar, olive oil, and grapeseed oil, may inhibit the conversion of choline, betaine, and carnitine to TMA
