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In addition, high-dose VitC also has more effect on mismatch repair (MMR)-deficient tumors than on MMR-competent ones, suggesting that the antitumor effect of VitC is enhanced in tumors harbouring increased mutational/neoantigen burdens [91]

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However, in recent years it has also been unequivocally demonstrated that not only effective reduction of cholesterol concentration according to the rule of the lower the better is important, but that achievement of the therapeutic goal for LDL-C as soon as possible, according to the rule of the earlier the better, and maintaining it as long as possible (= the longer the better), is also of critical importance [2, 6, 7, 106]

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