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The efficacy of GLP-1 medications is consistent with actions of other antiinflammatory agents, such as IL-1 antagonists and colchicine, in reducing cardiovascular events (63, 64)

In lactating rats, tirzepatide was detected in milk, though the clinical significance of these findings for humans is uncertain due to physiological differences between species

Further analyses of differentially expressed genes between GLP-1MK-801 and semaglutide treatment groups support this notion by showing enrichment of functional terms pertaining to glutamatergic signalling and synaptic plasticity among the most upregulated genes

Important Context: Clinical trial results represent averages across study populations