had taken, within 3 months before visit 2, medications (prescribed or over-the-counter) or alternative remedies that promote weight loss Examples included, but were not limited to Saxenda (liraglutide 3.0 mg) Xenical/Alli (orlistat) Meridia (sibutramine) Acutrim (phenylpropanolamine) Sanorex (mazindol) Apidex (phentermine) BELVIQ (lorcaserin) Bontril (phendimetrazine) Qsymia (phentermine/topiramate combination) Contrave (naltrexone/bupropion) Note: use of metformin, or any other glucose-lowering medication, whether prescribed for polycystic ovarian syndrome or diabetes prevention, was not permitted
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is supported by the American Heart AssociationBristol Myers Squibb Foundation through the Winn Diversity in Clinical Trials Clinical Investigator Leadership Award, and by the National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Physician-Scientist Career Development Award, Grant Number K12DK133995 (David Maahs, Linda DiMeglio, Multi-Center Program Directors)
They require proper patient selection, careful dose titration, side effect monitoring, nutritional counseling to prevent lean mass loss, and long-term follow-up planning
3.2 Results of MR Table 1 showed results of MR and Table 2 showed results of sensitivity analysis
