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In order to substantiate the therapeutic potential of JMF4073 for TKI-resistant T315I-Bcr-Abl cells, we investigated the mechanism responsible for the differential response to JMF4073

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GLP-1R agonist analogues with turn-promoting -amino acids are more active than those with helix-promoting -amino acids at the fourth position Non-traditional substitutions can yield GLP-1 analogues that show distinctive behavior and these might also provide insight into agonist conformation