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Type I interferons, such as IFN- and IFN-, produced by plasmacytoid dendritic cells can lead to multiple, diverse, downstream actions (30, 31), differentiation of CD8+ T cells into cytolytic effector cells (32), downregulation of T regulatory cells (33), reduction in IL-12p40 (34), and upregulation of IL15 together with further lymphocyte expansion (30)

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