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10.1016/S0020-7292(01)00494-5 121 NikooS.EbtekarM.Jeddi-TehraniM.ShervinA.BozorgmehrM.KazemnejadS.et al (2012)

His serum and urinary concentrations of VPA were 1316.2 and 3289.5 g/ml, respectively

In a rat model of PH induced by hypoxia at 6,000 m altitude, halofuginone blocks the inflammatory cascade by inhibiting TGF-1 expression and Smad2/3 phosphorylation, significantly reducing the levels of IL-1, IL-6, and TNF- in lung tissues, inhibiting the infiltration of neutrophils and lymphocytes, improving inflammatory damage to vascular walls, and decreasing the right ventricular hypertrophy index and pulmonary vascular wall thickness (Wang et al., 2025)

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