retatrutide vs semaglutide vs tirzepatide Retatrutide: 2026 Chicago Guide Semaglutide vs. Tirzepatide vs. Retatrutide:

Combined with reduced appetite from GLP-1 and GIP signaling, the result is faster and larger weight loss than anything currently approved

Red flags requiring immediate evaluation include severe abdominal pain (possible pancreatitis), persistent vomiting leading to dehydration, suicidal thoughts, development of new eating disorder behaviors, syncope, chest pain, hematemesis/melena, severe constipation/obstipation, orthostatic hypotension, or marked electrolyte abnormalities

Protein powder can help you hit targets, but also eat actual chicken, fish, eggs, and yogurt

Provides continuous subcutaneous insulin infusion