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Positive expression of GLP-1R is detected in the GCL of olfactory bulb (Thiebaud et al., 2016)

20, 2024, the FDA approved tirzepatide (Zepbound) for the treatment of moderate-to-severe OSA in adults with obesity, with and without positive airway pressure (PAP) therapy, making it the first GLP-1 indicated for OSA

Notably, Through a feedback mechanism, mTORC1 inhibition may momentarily increase mTORC2 signaling, causing temporary metabolic disruptions during the first phase of treatment (224), which can transiently disrupt metabolism and frequently leads to hyperlipidemia, necessitating concomitant lipid-lowering therapy (237239)

None of the three compounds have safety data in this context