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Oxidative stress happens through several ways: Homocysteine goes through oxidation and auto-oxidation [18] Low folate reduces antioxidant enzyme activities, including superoxide dismutase and glutathione peroxidase [18] These changes create an environment that hurts cell function [18] Folate supplements can work as antioxidants by lowering homocysteine levels and boosting intraerythrocyte glutathione directly [19]

Safety concerns also emerged, with drugs like Acomplia and Belviq ultimately withdrawn from the market for psychiatric risk and cancer risk respectively

If nausea becomes severe or persistent, it is important to consult your GP, as dose adjustment or additional supportive measures may be required