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168 Indeed, liver biopsies confirm that the prevalence of clinically significant fibrosis in MASLD and MASH patients is only 20.27% and 35.14%, respectively, 169 with lower proportions in patients with normal or lean body weight, 170 suggesting that antifibrotic treatment may not be necessary for a larger proportion of patients

Meta-analyses suggest that they reduce triglycerides and waist circumference, although their effects on total cholesterol and LDL-C are inconsistent (85)

Researchers are exploring nanoparticle carriers, enzyme inhibitors, and absorption enhancers to make daily oral GLP-1s easier to take and potentially more effective

The company started selling a compounded version of semaglutide last year, when the drug was still on the FDA's shortage list