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Description

Brown L, Rosner B, Willett WW, Sacks FM

Although KPV isnt yet an FDA-approved drug with widespread human use, these practical perspectives have allowed us to deduce its relative position in the larger peptide landscape

Unlike the Cagri-CTR-Gs complexes, in the CagriBB-bound CTR H296 ECL2 adopted the inward rotamer position that was observed when bound to other non-lipidated peptides, and ECL3 formed the more closed conformation in both experimental repeats