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Name: tirzepatide stops working Dosing What is the latest update
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Yamada, Y., Katagiri, H., Hamamoto, Y., Deenadayalan, S., Navarria, A., Nishijima, K., Seino, Y., & PIONEER 10 Investigators

This reduced response is driven by insulin resistance, diabetic medications (some of which promote weight gain), and metabolic dysfunction that blunts the full effect of GLP-1 therapy

Understanding the gap between efficacy in randomized controlled trials and effectiveness in real-world use of GLP-1 RA and DPP-4 therapies in patients with type 2 diabetes