Chronic hypoxia drives the conversion of Tregs to pro-inflammatory Th17 cells via the HIF-1 pathway, characterized by reduced CD25 expression, increased OX40 expression, and exhaustion of immunosuppressive function, which exacerbates Th1/Th17 cell polarization and the release of pro-inflammatory factors such as IL-17A and IFN- (Lantz et al., 2024)
Ryan DH, Yockey SR (2017) Weight loss and improvement in comorbidity: differences at 5%, 10%, 15%, and over
"[now] I can maybe do one or two light beers, and that's it, whereas before, I could drink, like, five IPAs in a sitting, so I definitely drink a lot less." Amy, another GLP-1 user, puts it simply: "I just don't have the desire to drink a lot anymore." Gone are the days of lingering over a second or third glass of wine
Lancet 2018;392:13841386