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This causes inflammation as the immune system causes cellular injury

Neurotoxicology 45:131138 Duan J, Xiaokaiti Y, Fan S, Pan Y, Li X, Li X (2017) Direct interaction between caffeic acid phenethyl ester and human neutrophil elastase inhibits the growth and migration of PANC-1 cells

The short answer: it depends but a reasonable expectation is: At 4 weeks : subtle internal changes and gentle lightening At 8 weeks : more visible brightening and evenness At 12 weeks : notable improvements in tone, radiance, and pigmentation Keep in mind that studies show positive changes in glutathione levels and skin brightness over 412 weeks

Categorical data were described using frequencies and percentages, and differences between groups were analyzed using the chi-square test or Fishers exact test