This is because tirzepatide is not just a GLP-1 receptor agonist but also a GIP receptor agonist, making it more potent in some respects and potentially more likely to cause gastrointestinal side effects in the early weeks
Heres what we learned about midlife GLP-1 use in 2025
It also modulates non-coding RNAs, up-regulating tumor-suppressive miRNAs (e.g., miR-34a, miR-200c) and down-regulating oncogenic ones (e.g., miR-21, miR-19a), resulting in decreased proliferation and enhanced apoptosis ( 6 A) by regulating writer (METTL3/METTL14), eraser (ALKBH5/FTO), and reader (YTHDF1/2) proteins, thereby altering mRNA stability and translation in cancer, inflammatory, and metabolic contexts (Sun et al., 2024
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