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The Lancet 2023,402(10403),705719 Wharton, S., Blevins, T., Connery, L., et al

The key difference lies in regulatory pathway, not therapeutic mechanism

The effects of GLP-1ag on obesity, insulin resistance, inflammation, sleep apnoea and other CVRFs position this group of drugs favourably for the treatment of polycystic ovary syndrome and obesity-associated infertility.35 SEMA 2.4 mg has been shown to be effective in reducing symptoms of osteoarthritis of the knee in obese individuals after 68 weeks of treatment, probably related to the reduction in weight, adipocyte dysfunction and the anti-inflammatory effect of the molecule.36 Favourable effects of SEMA have also been reported in patients with hidradenitis suppurativa and psoriasis, probably related to its anti-inflammatory effect

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