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Patch testing is the minimum safety step, and avoidance is the safer choice

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Second, brain-mediated autonomic effects are exactly the kind of physiology that is subject to adaptation and counter-regulation over time, which is the mechanistic basis for the tachyphylaxis concern examined below

Consequently, the twin constrains of low oxygen supply dictated by renal structure and high oxygen demand dictated by renal function conspire to make the kidney particularly vulnerable to physiologic and environmental stresses that cause ischemia