Beyond its studied influence on rest and stress, preclinical research has explored DSIPs potential involvement in neuronal resilience and mitochondrial function, suggesting a broader neuroprotective role that may complement its primary effects on sleep quality and circadian alignment
These peripheral and central deficits can include severe gastrointestinal lesions, intracranial (superior sagittal sinus) hypertension, brain swelling and lesions, portal and caval hypertension, aortic hypotension, peripheral and central thrombosis, inferior caval vein and superior mesenteric vein congestion, azygos vein failure, electrocardiogram (ECG) disturbances, and heart, lung, liver, and kidney lesions (Vukojevic et al., 2018
While excessive levels of ROS can cause apoptosis in cancer cells, moderate ROS levels promote tumor development and progression (49)
Although tamoxifen and its metabolites (i.e., 4-hydroxytamoxifen) can cross the blood-brain barrier, these compounds have reduced bioavailability in the brain compared to other tissues 34