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Adherence leads to clinically meaningful weight loss An average of 15.67 % weight loss was reported within 12 months after treatment initiation among patients with ideal adherence

Over the past few years, we have seen the vital roles the metal nanomedicines play in the GSH-responsive and -exhausting strategies, and inorganic nanomaterials, MOFs, and platinum-based nanomaterials-mediated GSH depletion is expected to realize more powerful synergistic therapy based on rational design

The most common side effects are gastrointestinal, including nausea (15-20% of patients), diarrhea (9-10%), vomiting (8-9%), and abdominal pain (6-8%)

These medications do not directly increase metabolic rate or fat oxidation in the manner that exercise does