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Any receptor that is stimulated continuously tends to become less responsive over time it down-regulates

The tumor-bearing mice were intravenously administered Cy7.5-labeled NP4 at a dosage of 2 mg/kg (Ru) once the tumor volume reached approximately 200 mm

Preclinical research suggests neuroprotective effects, reduced inflammation, and potential benefits for cognition, but translating these findings to clinical mental health outcomes requires cautious interpretation