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183 However, in vitro both of these mechanisms were not responsible for insulins drastic enhancement of cytotoxicity of the folic acid analog methotrexate to MCF-7 human breast cancer cells

Finally, in vitro studies have shown the potential of NAC (1nM) to disassemble fibrils, protofibrils, oligomers and dimers of A molecules by blocking continuity in their oligomerization, a phenomenon mediated by the formation of hydrogen bridges between the A molecule and NAC, and by the stabilization of the neprilysin protease which is part of the catabolic equilibrium of the A peptide [70,71,72]

Arrows indicate the direction of carnitine transport across cellular membranes

5 Carnitine and fatigue Fatigue is the most common symptom experienced by patients with cancer [65]