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Higher doses do not improve efficacy and may increase side effects
The anti-amyloid antibodies of the 2020s, the first drugs ever to bend the course of the disease at all, did it the hard way: enormous multi-country trials with pre-specified cognitive endpoints, full publication in the New England Journal of Medicine and JAMA , and a brutal public fight over whether their modest benefit was even worth the brain-swelling risk
Is a Calorie Deficit Enough to Lose Weight
While there have been concerns over the drug leading to suicidal ideation, a preliminary FDA evaluation released in January 2024 failed to find evidence that Ozempic caused suicidal thoughts or tendencies
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